Antiretroviral drugs COVID have been controversial since they were developed in response to coronavirus infection, despite evidence that they are safe and effective. One of the concerns is whether the vaccine is safe for pregnant women. Recently review looked at the evidence in North America, Israel and Europe. African journalist Ozayr Patel asked anti-cancer expert Marta C. Nunes to compile the findings.
How do you gather evidence?
The current COVID-19 vaccine has not been tested in pregnant women in the first clinical trial. But in many countries, pregnant women get the vaccine. Experimental studies have been conducted since the vaccine was developed, to provide information on the safety of the vaccine and how well it works.
We reviewed more than 30 studies from different countries with data on pregnant women and COVID contraceptives.
What did you find?
We divided our research into three parts: safety; immunogenicity (strength of immune response); and safety effects.
The question is whether it is safe to vaccinate pregnant women with COVID. None of the studies have identified any safety concerns about these vaccines during pregnancy. Reactions to vaccines reported by pregnant women were similar to those reported by other adults who received the vaccine. There is no difference between pregnant women and society in terms of safety.
The second factor is immunogenicity: how the immune system responds to the vaccine. The response of pregnant women to the vaccine is similar to the response of non-pregnant women. Basically, they have the same level of immunity after vaccination. And these vaccines can cross the placenta. Immunizations can be found in the newborn’s umbilical cord, possibly giving the baby protection in the first few months of life.
The third part of the study focused on the protective effects of antibiotics. It looked at whether any vaccine protects pregnant women against COVID-19. There have not been many studies investigating this. But recent studies have found that mothers who receive COVID are protected against the disease as well as their babies. Vaccination of pregnant women is like vaccinating other adults. The great advantage is that it also protects babies.
Should women receive the vaccine?
We support it. This is because many studies, including our own study research department in unpublished South Africa, show that pregnant women and those exposed to COVID have a higher risk of miscarriage. Some studies have also shown that women who receive COVID during pregnancy have a higher risk of miscarriage. So it is very important to protect pregnant women against COVID-19.
What is the best vaccine for pregnant women?
Many studies and research we have looked at anti-mRNA drugs. This is because much of the study is in countries that are routinely vaccinated. That is why the World Health Organization is now recommended anti-mRNA drugs. Not many studies have looked at vector vaccines, for example Johnson & Johnson vaccines and AstraZeneca. Studies including the AstraZeneca and Johnson & Johnson vaccines have not found any problems with them. There are ongoing studies also looking at alternative vaccines.
What other vaccines do pregnant women get?
Vaccination of pregnant women is not a new idea. In South Africa, pregnant women receive tetanus vaccine. Influenza vaccine is also recommended for pregnant women. They are also provided with anti-tuberculosis (TB) and private health care systems in South Africa and many other countries. It is certainly not a new idea to give pregnant women contraceptives that have been shown to be safe and secure.
Data from low- and middle-income countries are scarce, though. It is important to get data from these countries because the population is different in some ways. We know that women in the African region may have some problems with women in the US tend to have. It will be useful to have studies and research from African countries or other low- and middle-income countries where the situation may vary.
COVID treatment in pregnancy: tests show no safety
Source link COVID treatment in pregnancy: tests show no safety